Tafika Zambezi is located within the Sapi Safari Area, about 40km downstream from Mana Pools National Park and just above the confluence of the Chewore and Zambezi Rivers. Just to the east is the famed Chewore North Safari Area.
Like Mana Pools and Sapi, Chewore is administered by Zimbabwe National Parks and Wildlife Authority. Across the river is Zambia's Lower Zambezi National Park. Collectively, and on both sides of the river, one of the largest, unspoiled, undeveloped and unpopulated wilderness areas in southern Africa thus surrounds Tafika Zambezi.